Leaderboards/Cell death mechanisms and regulation

Cell death mechanisms and regulation

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Md Entaz Bahar
Gyeongsang National University
2
Chi G. Weindel
Texas A&M Health Science Center
3
Jia-yuan Zhang
Xiamen University
4
Sabira Mohammed
University of Oklahoma Health Sciences Center
5
Xiaoyan Hu
Virginia Commonwealth University
6
Md. Saddam
Gopalganj Science and Technology University
7
Yaqi Zhou
Henan University
8
Yanxiang Meng
École Polytechnique Fédérale de Lausanne
9
Lioba Koerner
University of Cologne
10
Andreas Jenner
University of Cologne

Papers

1
Publication in Cell Death Discovery (2024) [81 citations, W4396222140]
Cell Death Discovery|2024
81 cit.
2
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis
Cell Death and Differentiation|2024
56 cit.
3
Impact of Mlkl or Ripk3 deletion on age-associated liver inflammation, metabolic health, and lifespan
GeroScience|2025
11 cit.
4
LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia
The Journal of Immunology|2025
3 cit.
5
Publication in The Journal of Experimental Medicine (2025) [3 citations, W4414510598]
The Journal of Experimental Medicine|2025
3 cit.
6
The regulation of the apoptotic pore—An immunological tightrope walk
Advances in immunology|2024
1 cit.
7
The BET protein inhibitor apabetalone (RVX-208) prevents doxorubicin-induced endothelial senescence
European Heart Journal|2024
1 cit.
8
Publication (2025) [W4416739511]
Unknown Journal|2025
0 cit.
9
Publication (2025) [W4416739671]
Unknown Journal|2025
0 cit.
10
Publication (2025) [W4416739743]
Unknown Journal|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Daniel A. Bachovchin
Memorial Sloan Kettering Cancer Center
2
Alexander W. Hird
Paras Hospitals
3
Elaine Cadogan
AstraZeneca (Singapore)
4
Zhigao Wang
Zhejiang Wanli University
5
Chunlin Zhuang
Second Military Medical University
6
Haiming Dai
Mayo Clinic in Arizona
7
Hang‐zi Chen
Xiamen University
8
Kristin L. Patrick
Texas A&M Health Science Center
9
Delong Jiao
National Institutes of Health
10
Tudor Moldoveanu
University of Arkansas Medical Center

Papers

1
MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis
Cell Death and Differentiation|2023
75 cit.
2
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome
Science Immunology|2022
50 cit.
3
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease
Redox Biology|2023
50 cit.
4
The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells
Investigative Ophthalmology & Visual Science|2022
48 cit.
5
The NLRP1 and CARD8 inflammasomes detect reductive stress
Cell Reports|2023
37 cit.
6
Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on osteoclastogenesis and angiogenesis
Bioactive Materials|2022
36 cit.
7
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome
Nature Chemical Biology|2022
36 cit.
8
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
Cell Reports|2023
36 cit.
9
Structural basis of BAK activation in mitochondrial apoptosis initiation
Nature Communications|2022
35 cit.
10
Crystallography-Guided Optimizations of the Keap1–Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides
Journal of Medicinal Chemistry|2022
29 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Xiaodong Wang
Shanghai Children's Medical Center
2
Guido Kroemer
Institut Universitaire de France
3
Douglas R. Green
St. Jude Children's Research Hospital
4
Shigekazu Nagata
The University of Osaka
5
Vishva M. Dixit
Molecular Oncology (United States)
6
John C. Reed
University of North Carolina at Chapel Hill
7
Junying Yuan
Chinese Academy of Sciences
8
Craig B. Thompson
Memorial Sloan Kettering Cancer Center
9
Andreas Strasser
The University of Melbourne
10
Michael E. Greenberg
Harvard University

Papers

1
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Cell|1997
7.3k cit.
2
Autophagy in the Pathogenesis of Disease
Cell|2008
7k cit.
3
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Cell|1999
6.6k cit.
4
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Cell|1997
5.7k cit.
5
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Science|1995
5.3k cit.
6
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Cell|1996
5.2k cit.
7
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Science|1997
4.9k cit.
8
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Cell|1998
4.4k cit.
9
Molecular characterization of mitochondrial apoptosis-inducing factor
Nature|1999
4k cit.
10
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature|2015
3.7k cit.

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