Leaderboards/Catalytic C–H Functionalization Methods

Catalytic C–H Functionalization Methods

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Roman Kleinmans
University of Münster
2
Tristan von Münchow
Institute for Sustainable Development
3
Peng‐Zi Wang
Central China Normal University
4
Jisoo Woo
University of Chicago
5
Le‐Cheng Wang
Dalian Institute of Chemical Physics
6
Chen‐Xu Liu
Shanghai Institute of Organic Chemistry
7
Renyu Guo
Bristol-Myers Squibb (Germany)
8
Wan‐Chen Cindy Lee
Boston College
9
Soumitra Agasti
University of Manchester
10
Javier Corpas
RWTH Aachen University

Papers

1
Photocatalysis Meets Copper Catalysis: A New Opportunity for Asymmetric Multicomponent Radical Cross-Coupling Reactions
Accounts of Chemical Research|2024
95 cit.
2
Cobaltaelectro‐Catalyzed C–H Activation for Central and Axial Double Enantio‐Induction
Angewandte Chemie International Edition|2024
49 cit.
3
Enantioselective C–H annulations enabled by either nickel- or cobalt-electrocatalysed C–H activation for catalyst-controlled chemodivergence
Nature Catalysis|2025
49 cit.
4
Single-Electron-Transfer-Mediated Carbonylation Reactions
Accounts of Chemical Research|2025
42 cit.
5
A general strategy for the amination of electron-rich and electron-poor heteroaromatics by desaturative catalysis
Nature Catalysis|2024
39 cit.
6
Boryl radical-mediated halogen-atom transfer (XAT) enables the Sonogashira-like alkynylation of alkyl halides
Chemical Science|2024
28 cit.
7
Carbon-Atom Scavengers Enable Divergent, Selective Carbon Deletion of Azaarenes
Journal of the American Chemical Society|2025
21 cit.
8
A General Copper‐Box System for the Asymmetric Arylative Functionalization of Benzylic, Propargylic or Allenylic Radicals
Angewandte Chemie International Edition|2024
18 cit.
9
Excited-state protonation and reduction enable the umpolung Birch reduction of naphthalenes
Chem|2024
18 cit.
10
Asymmetric C–H Amination via Fe(III)-Metalloradical Catalysis Featuring α-Fe(IV)-Aminyl Radicals as Key Intermediates
Journal of the American Chemical Society|2025
18 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Song Lin
Cornell University
2
Wangqing Kong
Wuhan University
3
Jin Xie
China Pharmaceutical University
4
Zhiwei Zuo
Chengdu Military General Hospital
5
Osvaldo Gutiérrez
University of California, Los Angeles
6
Xing‐Zhong Shu
State Key Laboratory of Chemical Engineering
7
David A. Nagib
The Ohio State University
8
Shaozhong Ge
National University of Singapore
9
Mengchun Ye
Nankai University
10
Suman De Sarkar
Indian Institute of Science Education and Research Kolkata

Papers

1
Electrochemically driven cross-electrophile coupling of alkyl halides
Nature|2022
309 cit.
2
Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations
Nature|2023
294 cit.
3
Reductive Cross-Coupling of Unreactive Electrophiles
Accounts of Chemical Research|2022
276 cit.
4
Radical Polarity
Journal of the American Chemical Society|2024
177 cit.
5
Nickel-Catalyzed Ligand-Controlled Selective Reductive Cyclization/Cross-Couplings
Accounts of Chemical Research|2023
151 cit.
6
Exploring Electrochemical C(sp <sup>3</sup> )–H Oxidation for the Late-Stage Methylation of Complex Molecules
Journal of the American Chemical Society|2022
145 cit.
7
Multiplicative enhancement of stereoenrichment by a single catalyst for deracemization of alcohols
Science|2023
142 cit.
8
Carbene reactivity from alkyl and aryl aldehydes
Science|2022
139 cit.
9
Intercepting Hydrogen Evolution with Hydrogen-Atom Transfer: Electron-Initiated Hydrofunctionalization of Alkenes
Journal of the American Chemical Society|2022
138 cit.
10
Highly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids
Nature Communications|2022
134 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Stephen L. Buchwald
Massachusetts Institute of Technology
2
Jin‐Quan Yu
Scripps Research Institute
3
Frank Glorius
University of Münster
4
John F. Hartwig
University of California System
5
Lutz Ackermann
Institute of Organic Chemistry
6
David W. C. MacMillan
Princeton University
7
Aiwen Lei
Chinese Academy of Sciences
8
Matthias Beller
Leibniz Institute for Catalysis
9
Masahiro Miura
Anges (Japan)
10
Chao‐Jun Li
McGill University

Papers

1
An overview of N-heterocyclic carbenes
Nature|2014
4.2k cit.
2
Photoredox Catalysis in Organic Chemistry
The Journal of Organic Chemistry|2016
3.1k cit.
3
Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations
Accounts of Chemical Research|2008
2.8k cit.
4
Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions
Accounts of Chemical Research|2011
2.7k cit.
5
Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reactions Employing Dialkylbiaryl Phosphine Ligands
Accounts of Chemical Research|2008
2.6k cit.
6
Merging Photoredox Catalysis with Organocatalysis: The Direct Asymmetric Alkylation of Aldehydes
Science|2008
2.4k cit.
7
The advent and development of organocatalysis
Nature|2008
2.4k cit.
8
C–H bond activation enables the rapid construction and late-stage diversification of functional molecules
Nature Chemistry|2013
2.4k cit.
9
Using carbon dioxide as a building block in organic synthesis
Nature Communications|2015
2.1k cit.
10
On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition‐Metal Complexes
Angewandte Chemie International Edition|2012
2.1k cit.

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