Leaderboards/Cancer-related Molecular Pathways

Cancer-related Molecular Pathways

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
James Cregg
Revolution Medicines (United States)
2
Maud Debaugnies
Université Libre de Bruxelles
3
Yifat Geffen
Broad Institute
4
Lisa Crozier
University of Dundee
5
Xingyu Peng
Nanchang University
6
Sigrid Uxa
University Hospital Leipzig
7
Jingkun Zeng
QB3
8
Shazia Sofi
University of Kashmir
9
Daniel Horn‐Ghetko
Max Planck Institute of Biochemistry
10
Li Gu
Sichuan University

Papers

1
Publication in Journal of Medicinal Chemistry (2025) [72 citations, W4408247136]
Journal of Medicinal Chemistry|2025
72 cit.
2
Publication in Journal of Medicinal Chemistry (2025) [40 citations, W4407898113]
Journal of Medicinal Chemistry|2025
40 cit.
3
Topical retinoid drug Adapalene: A new frontier in cancer treatment
Results in Chemistry|2024
32 cit.
4
Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
Nature Structural & Molecular Biology|2024
13 cit.
5
Publication in bioRxiv (Cold Spring Harbor Laboratory) (2026) [W7160707009]
bioRxiv (Cold Spring Harbor Laboratory)|2026
0 cit.
6
Publication in Nature (2026) [W7163892708]
Nature|2026
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Lincoln D. Stein
Ontario Institute for Cancer Research
2
Peter J. Campbell
Wellcome Sanger Institute
3
Odette Mariani
Institut Curie
4
Sabrina L. Spencer
University of Colorado Boulder
5
Mohammadamin Dehghani
Ahvaz Jundishapur University of Medical Sciences
6
Constadina Arvanitis
Stanford University
7
Stephanos Ioannidis
Forma Therapeutics (United States)
8
Matthew J. Bott
Memorial Sloan Kettering Cancer Center
9
Josef Leibold
Universitätsklinikum Tübingen
10
Tinghu Zhang
Stanford University

Papers

1
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
Cell|2023
175 cit.
2
The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal
Nature Communications|2023
73 cit.
3
Cyclin E/CDK2 and feedback from soluble histone protein regulate the S phase burst of histone biosynthesis
Cell Reports|2023
37 cit.
4
Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles
Science Signaling|2023
24 cit.
5
Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids
Cell Reports|2023
23 cit.
6
Outcomes of Patients Undergoing Segmentectomy for Occult Node-Positive Clinical Stage IA Lung Cancer
The Annals of Thoracic Surgery|2024
23 cit.
7
Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
Nature Cancer|2024
21 cit.
8
Characterizing a learning curve for robotic-assisted bronchoscopy: Analysis of skills acquisition in a high-volume academic center
Journal of Thoracic and Cardiovascular Surgery|2024
20 cit.
9
Feasibility of shape-sensing robotic-assisted bronchoscopy for biomarker identification in patients with thoracic malignancies
Journal of Thoracic and Cardiovascular Surgery|2022
16 cit.
10
Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy
Nature Communications|2025
9 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Bert Vogelstein
Johns Hopkins University
2
Arnold J. Levine
Institute for Advanced Study
3
Tyler Jacks
Massachusetts Institute of Technology
4
Moshe Oren
Weizmann Institute of Science
5
David Beach
Hitachi (Japan)
6
David P. Lane
Science for Life Laboratory
7
Stephen J. Elledge
Howard Hughes Medical Institute
8
Peter M. Howley
Harvard University
9
Karen H. Vousden
The Francis Crick Institute
10
Scott W. Lowe
Memorial Sloan Kettering Cancer Center

Papers

1
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Analytical Biochemistry|1983
25.2k cit.
2
Genetic Alterations during Colorectal-Tumor Development
New England Journal of Medicine|1988
6.8k cit.
3
Surfing the p53 network
Nature|2000
6.6k cit.
4
Mdm2 promotes the rapid degradation of p53
Nature|1997
4.5k cit.
5
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
Proceedings of the National Academy of Sciences|1999
4.2k cit.
6
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Cell|1990
4k cit.
7
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
Nature|1993
3.7k cit.
8
p21 is a universal inhibitor of cyclin kinases
Nature|1993
3.4k cit.
9
Regulation of p53 stability by Mdm2
Nature|1997
3.3k cit.
10
A simplified system for generating recombinant adenoviruses
Proceedings of the National Academy of Sciences|1998
3.2k cit.

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