Leaderboards/Cancer, Hypoxia, and Metabolism

Cancer, Hypoxia, and Metabolism

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
McLane J. Watson
Vanderbilt University Medical Center
2
Yun-Zi Mao
Obstetrics and Gynecology Hospital of Fudan University
3
Taegeun Bae
Hanyang University
4
Yangzi Chen
Tsinghua University
5
Emeline Dierge
UCLouvain
6
Dirk Mossmann
University of Basel
7
Ilaria Elia
Cell Technology (China)
8
Yi Xiao
Fudan University Shanghai Cancer Center
9
Anirudh Sattiraju
Allen Institute for Brain Science
10
Oxana Dmitrieva-Posocco
University of Pennsylvania

Papers

1
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
Cell Research|2024
292 cit.
2
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Experimental & Molecular Medicine|2024
270 cit.
3
Publication in Nature Communications (2024) [204 citations, W4392125974]
Nature Communications|2024
204 cit.
4
AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
Cell Metabolism|2025
7 cit.
5
Total Syntheses and Stereochemical Assignment of Acremolides A and B
Molecules|2024
2 cit.
6
ARROW: Allele-Specific Recombined gRNA Design for Reduced Off-Target with Enhanced Specificity
Bioengineering|2025
2 cit.
7
Publication in Trends in Endocrinology and Metabolism (2025) [1 citation, W4414107595]
Trends in Endocrinology and Metabolism|2025
1 cit.
8
Abstract PO1-16-03: GDP-mannose enhances the efficacy of PARP inhibitors and immunotherapy in triple-negative breast cancer
Cancer Research|2024
0 cit.
9
Q&A with Ilaria Elia
Cell Reports|2024
0 cit.
10
Publication in Neuro-Oncology (2025) [W4416085439]
Neuro-Oncology|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Katrien De Bock
ETH Zurich
2
Weiwei Yang
Center for Excellence in Molecular Cell Science
3
Kellen Olszewski
Princeton University
4
Changtao Jiang
Peking University
5
Liangzhu Feng
Soochow University
6
Katherine Tarvin
National Institutes of Health
7
Erin Curley
Christiana Care Health System
8
Na Yin
Chinese Academy of Medical Sciences & Peking Union Medical College
9
Mingbin Zheng
Songshan Lake Materials Laboratory
10
Daniele M. Gilkes
Johns Hopkins University

Papers

1
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway
Cell|2024
275 cit.
2
Gut bacteria alleviate smoking-related NASH by degrading gut nicotine
Nature|2022
211 cit.
3
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target
Science|2023
166 cit.
4
Ferrous ions doped calcium carbonate nanoparticles potentiate chemotherapy by inducing ferroptosis
Journal of Controlled Release|2022
80 cit.
5
Immunogenic nanomedicine based on GSH-responsive nanoscale covalent organic polymers for chemo-sonodynamic therapy
Biomaterials|2022
74 cit.
6
MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle
Communications Biology|2023
73 cit.
7
MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion
Nature Metabolism|2022
49 cit.
8
Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
Molecular Metabolism|2024
48 cit.
9
A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE
Cell|2025
46 cit.
10
Pyruvate Facilitates FACT‐Mediated <i>γ</i>H2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma
Advanced Science|2022
44 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Gregg L. Semenza
Johns Hopkins University
2
Peter J. Ratcliffe
University of Oxford
3
Adrian L. Harris
University of Oxford
4
William G. Kaelin
Broad Institute
5
Craig B. Thompson
Memorial Sloan Kettering Cancer Center
6
Amato J. Giaccia
University of Oxford
7
Napoleone Ferrara
Unknown
8
Chi V. Dang
Abramson Center for Jewish Life
9
M. Celeste Simon
Centrum für Integrierte Onkologie
10
Randall S. Johnson
Athena Group (United States)

Papers

1
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences|1995
6.2k cit.
2
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation
Science|2001
5.5k cit.
3
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Nature|1999
5.2k cit.
4
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Science|1989
5k cit.
5
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing
Science|2001
4.7k cit.
6
Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1
Molecular and Cellular Biology|1996
4k cit.
7
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Cell Metabolism|2006
3.9k cit.
8
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
Nature|1993
3.6k cit.
9
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
Cell|2001
3.3k cit.
10
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
Cell|1993
3.1k cit.

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