Leaderboards/14-3-3 protein interactions

14-3-3 protein interactions

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Papers

High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity

Nature Medicine|2024

68 cit.

Publication in Nature Communications (2025) [17 citations, W4408084221]

Nature Communications|2025

17 cit.

RediscMol: Benchmarking Molecular Generation Models in Biological Properties

Journal of Medicinal Chemistry|2024

15 cit.

14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state

Nature Communications|2025

11 cit.

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Nature Communications|2025

10 cit.

Publication in Journal of the American Chemical Society (2025) [9 citations, W4406893532]

Journal of the American Chemical Society|2025

9 cit.

Publication in Communications Chemistry (2024) [4 citations, W4400113529]

Communications Chemistry|2024

4 cit.

Stabilization of Native Protein–Protein Interactions with Molecular Glues: A 14-3-3 Case Study

Accounts of Chemical Research|2025

4 cit.

Publication in International Journal of Biological Macromolecules (2025) [4 citations, W4414874685]

International Journal of Biological Macromolecules|2025

4 cit.

Modulation of the 14-3-3σ/C-RAF “Auto”inhibited Complex by Molecular Glues

Journal of the American Chemical Society|2026

1 cit.

Emerging Leaders

Drafting the new consensus

Researchers

Nikolai N. Sluchanko

A N Bach Institute of Biochemistry

Yongqing Yang

China Agricultural University

Jawahar Sudhamsu

Institute for Structural Research

Jana Ognjenović

Frederick National Laboratory for Cancer Research

Diego Sepúlveda‐Falla

University Medical Center Hamburg-Eppendorf

Yakeel T. Quiroz

Harvard University

Jozef Hritz

Central European Institute of Technology

Dimitrios Tzalis

Philipps University of Marburg

Daniele Alaimo

Wren Laboratories (United States)

Colin Adrain

Queen's University Belfast

Papers

Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man

Nature Medicine|2023

189 cit.

Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia

Acta Neuropathologica|2022

89 cit.

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease

Proceedings of the National Academy of Sciences|2022

87 cit.

<i>APOE3</i> Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease

New England Journal of Medicine|2024

57 cit.

Structural basis for SHOC2 modulation of RAS signalling

Nature|2022

54 cit.

Plasma p‐tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease

Alzheimer s & Dementia|2022

52 cit.

Phosphorylated and Phosphomimicking Variants May Differ—A Case Study of 14-3-3 Protein

Frontiers in Chemistry|2022

42 cit.

Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease

Alzheimer s & Dementia|2022

39 cit.

White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia

Alzheimer s Research & Therapy|2022

34 cit.

Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease

Alzheimer s & Dementia|2023

33 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

Marc W. Kirschner

Harvard University

Michael B. Yaffe

Beth Israel Deaconess Medical Center

Reuben J. Shaw

Salk Institute for Biological Studies

Christian Ottmann

Institute of Chemistry and Chemical Technology

Richard Marais

Macclesfield College

David Barford

MRC Laboratory of Molecular Biology

Helen Piwnica‐Worms

Centre for Cancer Biology

Unknown

Papers

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Molecular Cell|2008

3.8k cit.

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

Cell|2015

3.7k cit.

Dynamic instability of microtubule growth

Nature|1984

3.4k cit.

A protein factor essential for microtubule assembly.

Proceedings of the National Academy of Sciences|1975

3.1k cit.

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Nature Cell Biology|2011

2.9k cit.

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Cell|2004

2.8k cit.

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Science|2010

2.6k cit.

A quantitative analysis of kinase inhibitor selectivity

Nature Biotechnology|2008

2.4k cit.

Comprehensive analysis of kinase inhibitor selectivity

Nature Biotechnology|2011

2.4k cit.

Cyclin is degraded by the ubiquitin pathway

Nature|1991

2.4k cit.

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