Ning Liu

In this paper, we study physical adversarial attacks on object detectors in the wild. Previous works mostly craft instance-dependent perturbations only for rigid or planar objects. To this end, we propose to learn an adversarial pattern to effectively attack all instances belonging to the same object category, referred to as Universal Physical Camouflage Attack (UPC). Concretely, UPC crafts camouflage by jointly fooling the region proposal network, as well as misleading the classifier and the regressor to output errors. In order to make UPC effective for non-rigid or non-planar objects, we introduce a set of transformations for mimicking deformable properties. We additionally impose optimization constraint to make generated patterns look natural to human observers. To fairly evaluate the effectiveness of different physical-world attacks, we present the first standardized virtual database, AttackScenes, which simulates the real 3D world in a controllable and reproducible environment. Extensive experiments suggest the superiority of our proposed UPC compared with existing physical adversarial attackers not only in virtual environments (AttackScenes), but also in real-world physical environments.

Plant cell-wall polysaccharides constitute the most abundant but recalcitrant organic carbon source in nature. Microbes residing in the digestive tract of herbivorous bilaterians are particularly efficient at depolymerizing polysaccharides into fermentable sugars and play a significant support role towards their host's lifestyle. Here, we combine large-scale functional screening of fosmid libraries, shotgun sequencing, and biochemical assays to interrogate the gut microbiota of the wood-feeding "higher" termite Globitermes brachycerastes. A number of putative polysaccharide utilization gene clusters were identified with multiple fibrolytic genes. Our large-scale functional screening of 50,000 fosmid clones resulted in 464 clones demonstrating plant polysaccharide-degrading activities, including 267 endoglucanase-, 24 exoglucanase-, 72 β-glucosidase-, and 101 endoxylanase-positive clones. We sequenced 173 functionally active clones and identified ~219 genes encoding putative carbohydrate-active enzymes (CAZymes) targeting cellulose, hemicellulose and pectin. Further analyses revealed that 68 of 154 contigs encode one or more CAZyme, which includes 35 examples of putative saccharolytic operons, suggesting that clustering of CAZymes is common in termite gut microbial inhabitants. Biochemical characterization of a representative xylanase cluster demonstrated that constituent enzymes exhibited complementary physicochemical properties and saccharolytic capabilities. Furthermore, diverse cellobiose-metabolizing enzymes include β-glucosidases, cellobiose phosphorylases, and phopho-6-β-glucosidases were identified and functionally verified, indicating that the termite gut micro-ecosystem utilizes diverse metabolic pathways to interconnect hydrolysis and central metabolism. Collectively, these results provide an in-depth view of the adaptation and digestive strategies employed by gut microbiota within this tiny-yet-efficient host-associated ecosystem.

Flexible low-voltage indium-gallium-zincoxide (IGZO) electric-double-layer transistors are fabricated on polyethylene terephthalate substrates at room temperature and proposed for energy-efficient artificial synapse application. The IGZO channel conductance and the gate voltage pulse are regarded as synaptic weight and synaptic spike, respectively. The energy consumption of our IGZO synaptic transistor is estimated to be as low as ~0.23 pJ/spike. Short-term synaptic plasticity and high-pass filtering behaviors are also mimicked in an individual IGZO synaptic transistor.

Failure of insulators leads to failure of transmission system and causes heavy loss to the power sector. This has necessitated helicopter inspection on transmission line. Therefore, localizing insulators in collected aerial image is an essential step for automatic fault detection. This paper proposes a localization method of multiple insulators with different angles in complex aerial image based on Orientation Angle Detection and Binary Shape Prior Knowledge (OAD-BSPK). Detect possible orientation angles of insulators preliminarily. For each possible angle, reserve insulator by its binary shape prior knowledge. Traverse all the possible angles, and multiple insulators can be localized in aerial image finally. This paper uses a large number of real aerial captured images as experimental images. The results show that this method can localize multiple insulators with different orientation angles in complex aerial image, and has higher positioning precision, lower computational complexity and lower time consuming compared with existing methods. This method can meet the requirements of insulators' real-time and accurate localization.

Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that occurs when blood supply is restored to ischemic brain tissue and is one of the leading causes of adult disability and mortality. Multiple pathological mechanisms are involved in the progression of CIRI, including neuronal oxidative stress and mitochondrial dysfunction. Isoliquiritigenin (ISL) has been preliminarily reported to have potential neuroprotective effects on rats subjected to cerebral ischemic insult. However, the protective mechanisms of ISL have not been elucidated. This study aims to further investigate the effects of ISL-mediated neuroprotection and elucidate the underlying molecular mechanism. The findings indicate that ISL treatment significantly alleviated middle cerebral artery occlusion (MCAO)-induced cerebral infarction, neurological deficits, histopathological damage, and neuronal apoptosis in mice. In vitro , ISL effectively mitigated the reduction of cell viability, Na + -K + -ATPase, and MnSOD activities, as well as the degree of DNA damage induced by oxygen-glucose deprivation (OGD) injury in PC12 cells. Mechanistic studies revealed that administration of ISL evidently improved redox homeostasis and restored mitochondrial function via inhibiting oxidative stress injury and ameliorating mitochondrial biogenesis, mitochondrial fusion-fission balance, and mitophagy. Moreover, ISL facilitated the dissociation of Keap1/Nrf2, enhanced the nuclear transfer of Nrf2, and promoted the binding activity of Nrf2 with ARE. Finally, ISL obviously inhibited neuronal apoptosis by activating the Nrf2 pathway and ameliorating mitochondrial dysfunction in mice. Nevertheless, Nrf2 inhibitor brusatol reversed the mitochondrial protective properties and anti-apoptotic effects of ISL both in vivo and in vitro . Overall, our findings revealed that ISL exhibited a profound neuroprotective effect on mice following CIRI insult by reducing oxidative stress and ameliorating mitochondrial dysfunction, which was closely related to the activation of the Nrf2 pathway.