Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic RatsBACKGROUND: This study was aimed to evaluate the protective effects of a novel anti-hyperglycemic "Mcy protein" isolated from the fruits of Momordica cymbalaria in streptozotocin induced- diabetes rat model. MATERIALS AND METHODS: Wild type and Streptozotocin induced diabetic male wistar albino rats were either treated with single intraperitoneal injection of 2.5 mg Mcy protein/kg body weight or acetate buffer daily for 30 days. Fasting blood glucose and, serum and tissue lipid levels were measured along with biochemical analysis for hepatic and renal function tests. RESULTS: Mcy protein significantly reduced the fasting blood glucose and, serum as well as tissue lipid levels (p<0.05), besides normalizing the levels of liver and kidney function markers in the treated diabetic rats when compared to the diabetic controls. Our studies also showed the pancreatic islet regeneration in Mcy treated rats. CONCLUSION: Mcy protein can alleviate hyperlipidemia and help manage diabetes by stimulating insulin secretion without evident toxic effects on liver and kidney.
Nano CuO–Ag‐catalyzed synthesis of some novel pyrano[2,3‐d] pyrimidine derivatives and evaluation of their bioactivitySreelakshmi Poola, Mahammad Sadik Shaik, Murali Sudileti et al.|Journal of the Chinese Chemical Society|2019 Abstract A simple, highly efficient, and green method is developed for the synthesis of pyrano[2,3‐d] pyrimidine derivatives via Knoevenagel and Michael addition in the presence of nano CuO–Ag as a catalyst. The structures of synthesized target compounds 5a–l were confirmed by spectral and elemental analysis and were screened for their antioxidant activity by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), H 2 O 2 , and NO methods. Their antibacterial activity against Gram‐negative bacteria Pseudomonas aeruginosa and Escherichia coli , against Gram‐positive bacteria such as Bacillus subtilis and Staphylococcus aureus , and antifungal activity against Candida albicans and Candida glabrata was also evaluated. The compounds showed higher bacterial activity than the standard used. Compounds 5b , 5d , 5g , 5h , and 5i exhibited higher free radical scavenging activity than the standard butylated hydroxy toluene (BHT). Compounds 5b , 5d , and 5h showed higher activity on Gram‐positive bacteria, and compounds 5b , 5d , 5h , and 5i showed higher activity on Gram‐negative bacteria than that of standard tetracycline. Compounds 5b , 5j , and 5l showed much higher antifungal activity against Candida globrata and C. albicans than that of standard Griseofulvin.