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Gustave J. Dammin

Brigham and Women's Hospital

Publishes on Renal Transplantation Outcomes and Treatments, Organ Transplantation Techniques and Outcomes, Organ Donation and Transplantation. 153 papers and 6.1k citations.

153Publications
6.1kTotal Citations
Renal Transplantation Outcomes and TreatmentsOrgan Transplantation Techniques and OutcomesOrgan Donation and TransplantationOrgan and Tissue Transplantation ResearchXenotransplantation and immune response

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Top publicationsby citations

Prolonged Survival of Human-Kidney Homografts by Immunosuppressive Drug Therapy
Joseph E. Murray, John P. Merrill, J. Hartwell Harrison et al.|New England Journal of Medicine|1963
Cited by 549

THIS report is a summary of our experience with kidney homografts in 13 patients treated with drugs as the sole modality for the suppression of immunity (Table 1). Five recent cases are reported in detail: 1 patient with a cadaveric kidney is still alive after one year; 1 died from cerebral hemorrhage more than five months after transplantation from an unrelated infant; 1 is alive three months after transplant from his mother; the fourth is alive six weeks after receiving a kidney from his brother; and the fifth is living four weeks after a transplant from an unrelated adult volunteer. . . .

Alterations in the pathogenicity of Escherichia coli K-12 after transfer of plasmid and chromosomal genes from Shigella flexneri
Philippe Sansonetti, Thomas L. Hale, Gustave J. Dammin et al.|Infection and Immunity|1983
Cited by 298Open Access

A 140-megadalton plasmid (pWR110), which has previously been associated with virulence in Shigella flexneri, was transferred to Escherichia coli K-12. Segments of S. flexneri chromosomal material were then transferred to the plamid-bearing K-12 strains. The virulence of these transconjugant hybrids was assessed in the HeLa cell model, in ligated rabbit ileal loops, or in the Sereny test. A K-12 strain which harbored only pWR110 invaded HeLa cells, produced minimal lesions in the rabbit ileal mucosa, and was negative in the Sereny test. Plasmid-containing K-12 hybrids which had incorporated various shigella chromosomal regions gave differential reactions in the rabbit ileal loops and in the Sereny test. Analysis of these transconjugants indicated that three regions were linked with virulent phenotypes. These included the his region (when the genes responsible for O-antigen synthesis were cotransferred) and the kcp locus (linked to the lac-gal region). Either of these chromosomal regions was sufficient to allow invasion of the rabbit ileal mucosa. In addition to both of these regions, another shigella chromosomal segment linked to the arg and mtl loci was necessary for fluid production in the rabbit ileal loop and for a positive Sereny reaction. Thus, derivatives of an E. coli K-12 strain, constructed by the stepwise conjugal transfer of a large plasmid and three chromosomal segments from S. flexneri, appeared to contain the necessary determinants for full pathogenicity in a variety of laboratory models.