Cited by 373
Schlumberger (British Virgin Islands)
Publishes on Systemic Lupus Erythematosus Research, Spondyloarthritis Studies and Treatments, Rheumatoid Arthritis Research and Therapies. 91 papers and 1.5k citations.
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Abstract Synovial membranes from patients with rheumatoid arthritis and other arthritides were digested with tryps.n to produce suspensions of synovial cells. The cells were stained by the direct fluorescent antibody technique for IgG, IgM and the β 1c (C3) component of complement, using fluorescein and rhodamine isothiocyanate‐labeled antisera. A characteristic diffuse staining pattern for IgG and β 1c was observed in the cytoplasm of the phagocytic lining cells of rheumatoid synovium. In seropositive patients, inclusions containing IgG, IgM, and β 1c were also stained in these cells. The role of these immunoglobulins, localized in the lining cells, is discussed in relation to rheumatoid inflammation.
The incidence of cardiovascular lesions in 97 patients with ankylosing spondylitis (AS) was found to be 14%; 8 patients had isolated aortic insufficiency (AI), 3 had isolated heart block, 2 had combined AI and heart block, and 1 had mitral insufficiency. In comparison with control groups of 81 patients with rheumatoid arthritis and 99 random hospital patients there was no increased incidence of isolated heart block in patients with AS. Clinical and postmortem findings indicated that the cardiovascular lesions of some patients with AS may antedate articular disease and may regress spontaneously. In addition, the unusual occurrence of AI in two patients with psoriatic spondylitis and in one with AS and regional enteritis is documented.
Synovial tissues obtained at arthrotomy or by needle biopsy were digested with trypsin, and suspensions of synovial cells isolated. Immunofluorescent staining of these cells has shown the simultaneous presence of immunoglobulin G (IgG) and the β(1C) component of complement in the cytoplasm of most of the phagocytic lining cells of fifteen of seventeen synovia obtained from both seropositive and seronegative patients with rheumatoid arthritis. This staining pattern was not found in synovial cells obtained from patients with other inflammatory or non-inflammatory arthritides. Discrete cytoplasmic inclusions composed of: (1) IgG and α(1C), and (2) IgG and rheumatoid factor were also observed, but only in synovial cells from seropositive rheumatoid patients. The significance of the presence of an apparent IgG–β(1C) complex in the synovial lining cells of most patients with rheumatoid arthritis is discussed.