Cited by 1.8kOpen Access
Bridge Pharma (United States)
Publishes on Drug Transport and Resistance Mechanisms, Neuroscience and Neuropharmacology Research, Chemical Synthesis and Analysis. 335 papers and 16.8k citations.
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A series of 6alpha-alkyl-substituted analogues of chenodeoxycholic acid (CDCA) were synthesized and evaluated as potential farnesoid X receptor (FXR) ligands. Among them, 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA) was shown to be a very potent and selective FXR agonist (EC(50) = 99 nM) and to be endowed with anticholeretic activity in an in vivo rat model of cholestasis.