Zhengyuan Zhang

Chemical reprogramming of human somatic cells to pluripotent stem cells

Jingyang Guan, Guan Wang, Jinlin Wang et al.|Nature|2022

Cited by 369

Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient

Shusen Wang, Yuanyuan Du, Boya Zhang et al.|Cell|2024

Cited by 228

Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates

Yuanyuan Du, Zhen Liang, Shusen Wang et al.|Nature Medicine|2022

Cited by 149

Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds

Junqing Ye, Jian Ge, Xu Zhang et al.|Cell Research|2015

Cited by 85Open Access

Upregulation of CDCA5 promotes gastric cancer malignant progression via influencing cyclin E1

Zhengyuan Zhang, Mingyang Shen, Guangrong Zhou|Biochemical and Biophysical Research Communications|2018

Cited by 53Open Access

The cell division cycle associated 5(CDCA5) was reported to be associated with progression of several human cancers, however, its clinical significance and biological role still remain unknown in gastric cancer(GC). By analyzing The Cancer Genome Atlas(TCGA), we found CDCA5 was significantly upregulated in GC tissues compared to adjacent normal tissues. Tissue microarray(TMA) indicated upregulation of CDCA5 was significantly correlated with more advanced clinicopathological features, and acts as an independent risk factor for worse overall survival(OS) in GC patients. Moreover, silence of CDCA5 suppresses proliferation of GC cells by inducing G1-phase arrest via downregulating Cyclin E1(CCNE1). Our results demonstrate upregulation of CDCA5 promotes GC malignant progression, which may offer a potential prognostic and therapeutic strategy.

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