Yu-Jen Chen

Immunotherapy can potentially suppress the highly aggressive glioblastoma (GBM) by promoting T lymphocyte infiltration. Nevertheless, the immune privilege phenomenon, coupled with the generally low immunogenicity of vaccines, frequently hampers the presence of lymphocytes within brain tumors, particularly in brain tumors. In this study, the membrane-disrupted polymer-wrapped CuS nanoflakes that can penetrate delivery to deep brain tumors via releasing the cell–cell interactions, facilitating the near-infrared II (NIR II) photothermal therapy, and detaining dendritic cells for a self-cascading immunotherapy are developed. By convection-enhanced delivery, membrane-disrupted amphiphilic polymer micelles (poly(methoxypoly(ethylene glycol)-benzoic imine-octadecane, mPEG-b-C18) with CuS nanoflakes enhances tumor permeability and resides in deep brain tumors. Under low-power NIR II irradiation (0.8 W/cm2), the intense heat generated by well-distributed CuS nanoflakes actuates the thermolytic efficacy, facilitating cell apoptosis and the subsequent antigen release. Then, the positively charged polymer after hydrolysis of the benzoic-imine bond serves as an antigen depot, detaining autologous tumor-associated antigens and presenting them to dendritic cells, ensuring sustained immune stimulation. This self-cascading penetrative immunotherapy amplifies the immune response to postoperative brain tumors but also enhances survival outcomes through effective brain immunotherapy.

The purpose of this thesis is to design and analysis of passive pitch control. Design a mechanics to control different revolution of blade's pitch angle. The use of small wind turbines gradually popularization, but how to overcome the low wind speed start-up and the operation under high wind speed, that is the difficult problems encountered by designers. In order to extend the use and the safe of wind speed, this design is required. This paper is focus on the mechanism design of the passive pitch control for the small horizontal axis wind turbine (HAWT). When the wind speed is fast, the rotation speed is also faster and faster. The system uses centrifugal force to make Pulley disk driven the pitch angle of the blade. It can achieve the effect of passive pitch control. The mechanism is our laboratory's patent. Through the experiments in wind tunnel, it can be observed the variation of the performance curve when the pitch rotation. This system not only successfully operates under high wind speed but also has better performance at low wind speed.

Personnel inside health care facilities are mostly at a disadvantage during evacuation, therefore in the event of a fire, evacuation would possess certain difficulties and result in serious consequences. Use of conventional fire hydrants for fire extinction could damage equipment because of the amount of water used. To avoid this, the amount of water used was a key consideration during this study besides fire extinction performance. This research used newly developed mobile high pressure equipment and nozzle A with a K value of 3.7, and extinguished three standard wood cribs (7.5 MW), its performance being superior to that of the equipment used by the NRIFD (National Research Institute of Fire and Disaster).Using the equipment at a pressure of 49.3kgf/cm2 and discharge flow rate of 26 LPM, the time needed for extinction was 68s, 76s, and 60s,without any recrudescence within 2 min afterwards. Calculations showed that this system only required 33L of water for extinction, 27% less than the indoor hydrant, but was still effective, and it also showed no leakage of electricity under operation pressure and discharge flow rate. This research is a first to quantifiably analyze and compare the performance between mobile high pressure water mist equipment and indoor hydrants