Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaksJosé Alvim Berkenbrock, Rafaela Grecco-Machado, Sven Achenbach|Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences|2020 Extensive testing of populations against COVID-19 has been suggested as a game-changer quest to control the spread of this contagious disease and to avoid further disruption in our social, healthcare and economical systems. Nonetheless, testing millions of people for a new virus brings about quite a few challenges. The development of effective tests for the new coronavirus has become a worldwide task that relies on recent discoveries and lessons learned from past outbreaks. In this work, we review the most recent publications on microfluidics devices for the detection of viruses. The topics of discussion include different detection approaches, methods of signalling and fabrication techniques. Besides the miniaturization of traditional benchtop detection assays, approaches such as electrochemical analyses, field-effect transistors and resistive pulse sensors are considered. For emergency fabrication of quick test kits, the local capabilities must be evaluated, and the joint work of universities, industries, and governments seems to be an unequivocal necessity.
Influence of developer temperature and resist material on the structure quality in deep x-ray lithographyF. J. Pantenburg, Sven Achenbach, J. Mohr|Journal of Vacuum Science & Technology B Microelectronics and Nanometer Structures Processing Measurement and Phenomena|1998 Deep x-ray lithography is a fabrication method for the production of microstructures with aspect ratios of up to 100 in up to several millimeter thick resist layers. Usually, poly(methylmethacrylate) is used as the resist layer. We have measured the molecular weight and developing rates of crosslinked and noncrosslinked PMMA foils at different GG developer temperatures for dose values between 0.1 and 8 kJ/cm3. The determined developing rates cover a region of 7 orders of magnitude: With decreasing temperature the contrast of the resist-developer system and the limit of the developing dose are increased. Crosslinked PMMA has a higher contrast compared to noncrosslinked material. These effects lead to an enhanced quality of microstructures, which is demonstrated by the grating of the LIGA microspectrometer.