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Brigham and Women's Hospital
ORCID: 0000-0002-7741-3327Publishes on Neuroinflammation and Neurodegeneration Mechanisms, Tryptophan and brain disorders, Alzheimer's disease research and treatments. 46 papers and 3.5k citations.
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) production via nicotinamide phosphoribosyltransferase (NAMPT) inhibition demonstrated that metabolic catastrophe drives the combination-induced cytotoxicity. This study provides a comprehensive single-agent and combinatorial drug screen for DMG and identifies concomitant HDAC and proteasome inhibition as a promising therapeutic strategy that underscores underrecognized metabolic vulnerabilities in DMG.
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