Cited by 1.3kOpen Access
Morgan Stanley Children's Hospital
ORCID: 0000-0002-8971-993XPublishes on Liver Disease Diagnosis and Treatment, Esophageal and GI Pathology, Clinical Nutrition and Gastroenterology. 37 papers and 2.3k citations.
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Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.