Cited by 7.4kOpen Access
Broad Institute
ORCID: 0000-0002-1800-5112Publishes on Computational Drug Discovery Methods, Bioinformatics and Genomic Networks, Click Chemistry and Applications. 222 papers and 33.8k citations.
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To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.